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Overdose safety
Signs of an overdose and what to do. In an emergency, call 911.
ImportantSigns of an overdose
An overdose is an emergency. Call 911 right away if you see any of these signs. If you're not sure, treat it as an overdose.
- Can't be woken up, or won't respond to your voice
- Slow, shallow, or stopped breathing
- Choking, gurgling, or snoring sounds
- Lips or fingernails turn blue, gray, or purple
- Skin is pale, blue, or cold
- Tiny "pinpoint" pupils that don't react to light
- Body is limp
Based on CDC. Not yet reviewed by a clinician.
Sources (3)
- 5 Things to Know About Naloxone
Centers for Disease Control and Prevention, 2024-05-02 - Preventing an Opioid Overdose: Know the Signs. Save a Life.
Centers for Disease Control and Prevention - If You Think Someone Is Overdosing
Centers for Disease Control and Prevention
What to do
Give naloxone if you have it, then call 911. Anyone can give naloxone, with or without medical training.
Stay with the person until help arrives. Most states have Good Samaritan laws that may protect you and the person overdosing from legal trouble when you call for help.
- Give naloxone
- Call 911
- Try to keep them awake and breathing
- Lay them on their side so they don't choke
- If they don't start breathing normally in 2 to 3 minutes, give a second dose of naloxone
- Stay with them and keep watching their breathing
Based on CDC, FDA, and MedlinePlus. Not yet reviewed by a clinician.
Sources (5)
- 5 Things to Know About Naloxone
Centers for Disease Control and Prevention, 2024-05-02 - Lifesaving Naloxone
Centers for Disease Control and Prevention, 2025-06-11 - Information about Naloxone and Nalmefene
U.S. Food and Drug Administration, 2024-08-08 - If You Think Someone Is Overdosing
Centers for Disease Control and Prevention - Naloxone Nasal Spray
MedlinePlus, National Library of Medicine, 2026-09-15
ImportantNever mix 7-OH with alcohol, sedatives, or other opioids
7-OH acts like an opioid. Opioids and sedatives both slow your breathing. Taken together, they can cause a fatal overdose.
- Alcohol
- Benzodiazepines, such as Xanax, Valium, or Klonopin
- Other opioids, including opioid pain pills like oxycodone or hydrocodone
- Xylazine ("tranq"), which can be mixed into street drugs
Based on NIDA and FDA. Not yet reviewed by a clinician.
Sources (2)
- Benzodiazepines and Opioids
National Institute on Drug Abuse, 2022-11-07 - FDA and Kratom
U.S. Food and Drug Administration
ImportantYour tolerance drops after you stop
After you stop, your body loses its tolerance. An amount you used to take can now cause an overdose. Most opioid overdose deaths happen in people who have just gone through withdrawal.
If you use again, carry naloxone and keep it at home.
Based on MedlinePlus and CDC. Not yet reviewed by a clinician.
Sources (2)
- Opiate and opioid withdrawal
MedlinePlus, National Library of Medicine, 2026-05-15 - Lifesaving Naloxone
Centers for Disease Control and Prevention, 2025-06-11
Getting naloxone
You don't need a prescription to buy naloxone nasal spray. It is sold over the counter in all 50 states. Many local health departments, community programs, and syringe services programs give it out for free or at low cost. Keep it where you and the people close to you can find it, and tell them where it is.
Based on FDA and CDC. Not yet reviewed by a clinician.
Sources (3)
- Information about Naloxone and Nalmefene
U.S. Food and Drug Administration, 2024-08-08 - Lifesaving Naloxone
Centers for Disease Control and Prevention, 2025-06-11 - 5 Things to Know About Naloxone
Centers for Disease Control and Prevention, 2024-05-02
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