Questions and answers

7-OH (7-hydroxymitragynine) is found naturally in the kratom plant, but only in small amounts. It makes up less than 2% of the natural compounds in kratom leaf. The 7-OH products sold in stores, like tablets, gummies, and shots, have concentrated levels of 7-OH.

The FDA describes 7-OH as an opioid that can be more potent than morphine. It acts on the same brain receptors as other opioids.

Based on FDA. Not yet reviewed by a clinician.

As of October 22, 2026, 7-OH is not yet on the federal list of controlled drugs. In July 2025 the FDA recommended control of certain 7-OH products. On October 14, 2026, the DEA said it plans to temporarily place 7-OH in Schedule I, the most restricted group. This would apply to products with more than a set amount of 7-OH. The DEA can issue this order on or after November 13, 2026. It takes effect the day it is published.

At least 10 states already ban 7-OH, and state laws can be stricter than federal law. Check the rules where you live.

Based on FDA and the Federal Register. Not yet reviewed by a clinician.

Yes. The FDA says 7-OH can be misused because it binds to opioid receptors. The DEA says 7-OH products can lead to addiction and withdrawal symptoms.

Doctors have published cases of people with 7-OH use disorder. Most of the early FDA safety reports on 7-OH involved dependence or withdrawal. You are not alone, and it is not a personal failing.

Based on FDA, the Federal Register, and published case reports. Not yet reviewed by a clinician.

Opioid withdrawal is painful but usually not life threatening. Vomiting and diarrhea can cause dehydration. In some published 7-OH cases, people needed hospital care to get through withdrawal. One needed intensive care.

Get medical help if you can't keep fluids down or your symptoms keep getting worse. Call 911 if someone has trouble breathing or won't wake up. A clinician can offer medicines that make withdrawal easier.

Based on MedlinePlus and published case reports. Not yet reviewed by a clinician.

Your tolerance drops after you stop. If you use again, even a smaller amount than you used to take can cause an overdose. Most opioid overdose deaths happen in people who have just gone through withdrawal.

If you do use again, carry naloxone and keep it at home.

Based on MedlinePlus and CDC. Not yet reviewed by a clinician.

Evidence suggests it does. The DEA describes a case where a man's breathing problems from 7-OH were reversed with a standard opioid reversal drug. In a study in rats, naloxone reversed breathing problems caused by 7-OH.

Naloxone will not harm someone who is not overdosing on an opioid. If you think someone is overdosing, give naloxone and call 911. More than one dose may be needed. Stay with the person until help arrives.

Based on the Federal Register, published research, and CDC. Not yet reviewed by a clinician.